Drug

# Drug 
## Drug names
| General name | 名称 | note|
|:-----|:-----|:-----|
|Truvada||emtricitabine / tenofovir|
|Melatonin|褪黑素||
|Tadalafil|||
|Sildenafil|||
|Orlistat|奥利司他|
## source
* [Drugs.com](https://www.drugs.com/drug-interactions) by FDA.
* [Liverpool interactions](https://www.hiv-druginteractions.org/checker) by University of Liverpool
* [eHealthMe](https://www.ehealthme.com/)
## Interactions
* Orlistat & Truvada
	* Liverpool 
Coadministration has **not been studied**. Orlistat should only be used with emtricitabine/tenofovir-DF if **separated by 4-5 hours**. Orlistat reduces dietary fat absorption and may affect the absorption of antiretrovirals (especially if lipophilic). [Note: this interaction is **not specific** for emtricitabine/tenofovir-DF, but for any medication taken with orlistat.]
	* Drugs.com
	Orlistat may theoretically reduce the gastrointestinal absorption and therapeutic efficacy of antiretroviral agents. The mechanism may involve retention of lipophilic medicines in the gastrointestinal tract or reduced gastrointestinal tract transit time. Data have been reported for efavirenz and lopinavir. Other antiretroviral agents may also be affected.

* Tadalafil &  food
	* Drugs.com
		* Tadalafil can lower blood pressure, and combining it with **alcohol** may further increase this effect. You may be more likely to experience symptoms such as dizziness, lightheadedness, fainting, flushing, headache, and heart palpitations. You should avoid or limit the use of alcohol while being treated with tadalafil, and use caution when getting up from a sitting or lying position. 
		* Coadministration with **grapefruit juice**（葡萄柚汁） is likely to increase the plasma concentrations of tadalafil, which is primarily metabolized by CYP450 3A4. However, the interaction has not been studied. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit.
* Truvada(tenofovir) & food
	* Drugs.com
		* Food enhances the oral absorption and bioavailability of tenofovir, the active entity of tenofovir disoproxil fumarate. According to the product labeling, administration of the drug following a **high-fat meal increased** the mean peak plasma concentration **(Cmax)** and area under the concentration-time curve **(AUC)** of tenofovir by approximately 14% and 40%, respectively, compared to administration in the fasting state. However, administration with a light meal did not significantly affect the pharmacokinetics of tenofovir compared to administration in the fasting state. Food delays the time to reach tenofovir Cmax by approximately 1 hour. *Tenofovir disoproxil fumarate may be administered without regard to meals.*

# Food


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